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FOXS1, frequently inactivated by promoter methylation, inhibited colorectal cancer cell growth by promoting TGFBI degradation through autophagy-lysosome pathway

24 Jan 2025

Abstract excerpt

INTRODUCTION: Tumor suppressor gene (TSG) inactivation by epigenetic modifications contributes to the carcinogenesis and progression of colorectal cancer (CRC). Expression profiling and CpG methylomics revealed that a forkhead-box transcriptional factor, FOXS1, is downregulated and methylated in CRC. OBJECTIVES: To assess the biological functions and underlying mechanisms of FOXS1 in colorectal cancer. METHODS:...

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PMID: 39864590
DOI: 10.1016/j.jare.2025.01.037

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