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Article

DNMT3b affects colorectal cancer development by regulating FLI1 through DNA hypermethylation.

The Kaohsiung journal of medical sciences - 1 Apr 2023

Zhou Lei, Pan Li-Zhen, Fan Yue-Juan

Abstract excerpt

Friend leukemia integration 1 (FLI1) is an ETS transcription factor family member. Here, we identified cg11017065 as the most hyper-methylated cytosine and guanine (CpG) in colorectal cancer (CRC), which belongs to the FLI1 gene. Moreover, integrated bioinformatics prediction and analysis of our cohort showed that FLI1 expression was downregulated and DNA methylation was elevated in CRC. Bioinformatics prediction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

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Identifiers

PMID: 36655868
DOI: 10.1002/kjm2.12647

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