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Article

Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy.

Oncotarget - 14 Aug 2015

Zhai Haiyan, Fesler Andrew, Ba Yufeng, Wu Song, Ju Jingfang

Abstract excerpt

Colorectal cancer (CRC) is the third highest mortality cancer in the United States and frequently metastasizes to liver and lung. Smad2 is a key element downstream of the TGF-β signaling pathway to regulate cancer metastasis by promoting epithelial to mesenchymal transition and maintaining the cancer stem cell (CSC) phenotype. In this study, we show that hsa-miR-140-5p directly targets Smad2 and overexpression of...

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Identifiers

PMID: 25980495
DOI: 10.18632/oncotarget.3771
PMCID: PMC4637317

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