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Article

PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.

Cell death & disease - 19 Jun 2021

Ji Guangyu, Zhou Wenjuan, Du Jingyi, Zhou Juan, Wu Dong, Zhao Man, Yang Liping, Hao Aijun

Abstract excerpt

Colorectal cancer (CRC) stem cells are resistant to cancer therapy and are therefore responsible for tumour progression after conventional therapy fails. However, the molecular mechanisms underlying the maintenance of stemness are poorly understood. In this study, we identified PCGF1 as a crucial epigenetic regulator that sustains the stem cell-like phenotype of CRC. PCGF1 expression was increased in CRC and was...

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Identifiers

PMID: 34148069
DOI: 10.1038/s41419-021-03914-2
PMCID: PMC8214626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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