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MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling

27 Oct 2021

Abstract excerpt

BACKGROUND: Histone epigenetic modification disorder is an important predisposing factor for the occurrence and development of many cancers, including colorectal cancer (CRC). The role of MYSM1, a metalloprotease that deubiquitinates monoubiquitinated histone H2A, in colorectal cancer was identified to evaluate its potential clinical application value. METHODS: MYSM1 expression levels in CRC cell lines and tumor...

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PMID: 34706761
DOI: 10.1186/s13046-021-02106-2

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