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Article

FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression

25 Apr 2019

Abstract excerpt

F-box only protein 8 (FBX8), as a critical component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases, has been associated with several malignancies through interacting with a member of proteins. However, the substrates of FBX8 for destruction in the progression of colorectal carcinoma (CRC) need to be explored. Here, we show that loss of FBX8 accelerates chemical-induced colon tumorigenesis. FBX8 directly...

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PMID: 31024008
DOI: 10.1038/s41419-019-1588-z

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