Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues

1 Mar 2023

Abstract excerpt

Cardiac in vitro models have become increasingly obtainable and affordable with the optimization of human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) differentiation. However, these CMs are immature compared to their in vivo counterparts. Here we study the cellular phenotype of hPSC-CMs by comparing their single-cell gene expression and functional profiles in three engineered cardiac tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Pluripotent Stem Cells Research
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36950112
DOI: 10.1016/j.isci.2023.106302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissuesPMID 36950112Read ↗

Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term cultureSemantic proximity Read ↗

Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult MyocardiumSemantic proximity Read ↗

Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytesSemantic proximity Read ↗

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart DiseaseSemantic proximity Read ↗

Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes: a Critical Step for Drug Development and Cell Therapy.Semantic proximity Read ↗

Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseasesSemantic proximity Read ↗

Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production.Semantic proximity Read ↗

A three-dimensional culture system for generating cardiac spheroids composed of cardiomyocytes, endothelial cells, smooth-muscle cells, and cardiac fibroblasts derived from human induced-pluripotent stem cellsSemantic proximity Read ↗

Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug DiscoverySemantic proximity Read ↗

Generation of human chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseasesSemantic proximity Read ↗

Metabolically-Driven Maturation of hiPSC-Cell Derived Cardiac ChipSemantic proximity Read ↗

Single-cell atlas of multilineage cardiac organoids derived from human induced pluripotent stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.