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Article

Structure-guided engineering of a mutation-tolerant inhibitor peptide against variable SARS-CoV-2 spikes

24 Jan 2025

Abstract excerpt

Pathogen mutations present an inevitable and challenging problem for therapeutics and the development of mutation-tolerant anti-infective drugs to strengthen global health and combat evolving pathogens is urgently needed. While spike proteins on viral surfaces are attractive targets for preventing viral entry, they mutate frequently, making it difficult to develop effective therapeutics. Here, we used a...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 39854234
DOI: 10.1073/pnas.2413465122

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