Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.

doi:10.1172/JCI154987

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.

The Journal of clinical investigation - 15 Feb 2022

Zou Jia, Li Li, Zheng Peiyi, Liang Wenhua, Hu Siyi, Zhou Shuaixiang, Wang Yanqun, Zhao Jincun, Yuan Daopeng, Liu Lu, Wu Dongdong, Xu Mengqiu, Zhang Fangfang, Zhu Mengzhu, Wu Zhihai, Cao Xiaochao, Ni Meng, Ling Xiaomin, Wu Yue, Kuang Zhihui, Hu Moyan, Li Jianfeng, Li Xue, Guo Xiling, Xu Tianmin, Jiang Haiping, Gao Changshou, Yu Michael, Liu Junjian, Zhong Nanshan, Zhou Jianfeng, Huang Jian-An, Jin Tengchuan, He Jianxing

Abstract excerpt

Many SARS-CoV-2 neutralizing antibodies (nAbs) lose potency against variants of concern. In this study, we developed 2 strategies to produce mutation-resistant antibodies. First, a yeast library expressing mutant receptor binding domains (RBDs) of the spike protein was utilized to screen for potent nAbs that are least susceptible to viral escape. Among the candidate antibodies, P5-22 displayed ultrahigh potency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Viral

Share to Antibody Affinity

Share to Broadly Neutralizing Antibodies

Share to Immunization, Passive

Share to Neutralization Tests

Share to Receptors, Virus

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 35108220
DOI: 10.1172/JCI154987
PMCID: PMC8843702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.PMID 35108220Read ↗

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants.Semantic proximity Read ↗

Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects.Semantic proximity Read ↗

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognitionSemantic proximity Read ↗

Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effectsSemantic proximity Read ↗

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infectionSemantic proximity Read ↗

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralizationSemantic proximity Read ↗

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody RecognitionSemantic proximity Read ↗

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variantsSemantic proximity Read ↗

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.Semantic proximity Read ↗

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralizationSemantic proximity Read ↗

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variantsSemantic proximity Read ↗

Ultrapotent SARS-CoV-2 neutralizing antibodies effectively block new-emerging mutational variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.