Article

A macrocyclic peptide-based fusion inhibitor targeting SARS-CoV-2 Spike S2 subunit

2026-03-05

Abstract excerpt

Continuous emergence of SARS-CoV-2 variants carrying mutations in Spike presents a significant challenge for durable antiviral agents. Here we screen for random 13-amino acid non-mimetic macrocyclic peptides that bind to Spike and identify PA-001 that inhibits SARS-CoV-2 infection with high potency at 0.23–2.9 nM as 50% inhibitory concentration (IC 50 ). PA-001 bound to Spike S2 subunit and inhibited the membrane...

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Literature Corpus work: e5eccf89-b8ec-5845-89b1-87fa6fad7b41
DOI: 10.64898/2026.03.04.703990

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