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Article

Analyses of Human Genetic Data to Identify Clinically Relevant Domains of Neuroligins.

Genes - 14 Dec 2024

Lehr Alexander W, McDaniel Kathryn F, Roche Katherine W

Abstract excerpt

Background/Objectives: Neuroligins (NLGNs) are postsynaptic adhesion molecules critical for neuronal development that are highly associated with autism spectrum disorder (ASD). Here, we provide an overview of the literature on NLGN rare variants. In addition, we introduce a new approach to analyze human variation within NLGN genes to identify sensitive regions that have an increased frequency of ASD-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39766868
DOI: 10.3390/genes15121601

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