Article
Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models.
Nature communications - 5 Jul 2024
Wang Jun, Wang Meng, Moshiri Ala, Harris R Alan, Raveendran Muthuswamy, Nguyen Tracy, Kim Soohyun, Young Laura, Wang Keqing, Wiseman Roger, O'Connor David H, Johnson Zach, Martinez Melween, Montague Michael J, Sayers Ken, Lyke Martha, Vallender Eric, Stout Tim, Li Yumei, Thomasy Sara M, Rogers Jeffrey, Chen Rui
Abstract excerpt
Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequencing on 1845 individuals for 374 genes linked to inherited human retinal and neurodevelopmental diseases. We identify over 47,000 single nucleotide variants, a substantial proportion of which are shared...
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