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Article

Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system.

Protein & cell - 1 Nov 2013

Luan Guodong, Cai Zhen, Gong Fuyu, Dong Hongjun, Lin Zhao, Zhang Yanping, Li Yin

Abstract excerpt

Development of controllable hypermutable cells can greatly benefit understanding and harnessing microbial evolution. However, there have not been any similar systems developed for Clostridium, an important bacterial genus. Here we report a novel two-step strategy for developing controllable hypermutable cells of Clostridium acetobutylicum, an important and representative industrial strain. Firstly, the mutS/L...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24214875
DOI: 10.1007/s13238-013-3079-9
PMCID: PMC4875452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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