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The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank.

Human genomics - 17 Jan 2025

Sriram Vivek, Woerner Jakob, Ahn Yong-Yeol, Kim Dokyoon

Abstract excerpt

BACKGROUND: Disease comorbidities and longer-term complications, arising from biologically related associations across phenotypes, can lead to increased risk of severe health outcomes. Given that many diseases exhibit sex-specific differences in their genetics, our objective was to determine whether genotype-by-sex (GxS) interactions similarly influence cross-phenotype associations. Through comparison of...

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PMID: 39825454
DOI: 10.1186/s40246-024-00710-9
PMCID: PMC11740496

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