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Article

Uncovering genetic associations in the human diseasome using an endophenotype-augmented disease network.

Bioinformatics (Oxford, England) - 4 Mar 2024

Woerner Jakob, Sriram Vivek, Nam Yonghyun, Verma Anurag, Kim Dokyoon

Abstract excerpt

MOTIVATION: Many diseases, particularly cardiometabolic disorders, exhibit complex multimorbidities with one another. An intuitive way to model the connections between phenotypes is with a disease-disease network (DDN), where nodes represent diseases and edges represent associations, such as shared single-nucleotide polymorphisms (SNPs), between pairs of diseases. To gain further genetic understanding of...

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Biomarkers
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Endophenotypes
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Polymorphism, Single Nucleotide

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Identifiers

PMID: 38527901
DOI: 10.1093/bioinformatics/btae126
PMCID: PMC10963079

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