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The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick collection.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2025

Huber Hanna, Cantoni Valentina, Altomare Daniele, Grötschel Lana, Montoliu-Gaya Laia, Meda Francisco, Kvartsberg Hlin, Libri Ilenia, Cotelli Maria Sofia, Zetterberg Henrik, Blennow Kaj, Borroni Barbara, Ashton Nicholas J

Abstract excerpt

INTRODUCTION: Heterozygous mutations in the progranulin gene (GRN) leading to decreased progranulin levels are one of the most frequent causes of inherited frontotemporal dementia (FTD). We evaluated progranulin levels in dried blood spots from capillary finger-stick collection (DBScapillary). METHODS: Paired venous Ethylenediaminetetraacetic acid (EDTA) plasma and DBScapillary samples were collected from each...

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Identifiers

PMID: 39614734
DOI: 10.1002/alz.14259
PMCID: PMC11772735

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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