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Article

A Software Tool for Reagent Design to Expand Access to Single-Nucleotide Variant Detection by the Oligonucleotide Ligation Assay.

The Journal of molecular diagnostics : JMD - 1 Mar 2025

Nelson Dalton J, Chugh Kunal, Pua Heather H, Haselton Frederick R

Abstract excerpt

Single-nucleotide variants (SNVs) and polymorphisms are characteristic biomarkers in various biological contexts, including pathogen drug resistances and human diseases. Tools that lower the implementation barrier of molecular SNV detection methods would provide greater leverage of the expanding single-nucleotide polymorphism/SNV database. The oligonucleotide ligation assay (OLA) is a highly specific means for...

Read the complete abstract on PubMed

Topics

Humans
Polymorphism, Single Nucleotide
Software
SARS-CoV-2
COVID-19
HIV-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Mycobacterium tuberculosis

Polymerase Chain Reaction

Oligonucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 39818318
DOI: 10.1016/j.jmoldx.2024.12.007
PMCID: PMC12179523

Genes

BRAF
JAK2
KRAS

Provenance

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