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Development and Optimization of Oligonucleotide Ligation Assay (OLA) Probes for Detection of HIV-1 Resistance to Dolutegravir.

Viruses - 19 Jul 2024

Beck Ingrid A, Boyce Ceejay L, Bishop Marley D, Vu Yen L, Fung Amanda, Styrchak Sheila, Panpradist Nuttada, Lutz Barry R, Frenkel Lisa M

Abstract excerpt

The WHO currently recommends dolutegravir (DTG)-based ART for persons living with HIV infection in resource-limited-settings (RLS). To expand access to testing for HIV drug resistance (DR) to DTG in RLS, we developed probes for use in the oligonucleotide ligation assay (OLA)-Simple, a near-point of care HIV DR kit. Genotypic data from clinical trials and case reports were used to determine the mutations in HIV-1...

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Identifiers

PMID: 39066324
DOI: 10.3390/v16071162
PMCID: PMC11281587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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