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Article

Simultaneous and sensitive detection of human immunodeficiency virus type 1 (HIV) drug resistant genotypes by multiplex oligonucleotide ligation assay.

Journal of virological methods - 1 Sept 2013

Ellis Giovanina M, Vlaskin Tatyana A, Koth Andrew, Vaz Louise E, Dross Sandra E, Beck Ingrid A, Frenkel Lisa M

Abstract excerpt

Oligonucleotide ligation assay (OLA) is a highly specific and relatively simple method to detect point mutations encoding HIV-1 drug-resistance, which can detect mutants comprising ≥2-5% of the viral population. Nevirapine (NVP), tenofovir (TDF) and lamivudine (3TC) are antiretroviral (ARV) drugs used worldwide for treatment of HIV infection and prevention of mother-to-child-transmission. Adapting the OLA to...

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Identifiers

PMID: 23660583
DOI: 10.1016/j.jviromet.2011.11.030
PMCID: PMC3708483

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