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Article

OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories.

EBioMedicine - 1 Dec 2019

Panpradist Nuttada, Beck Ingrid A, Vrana Justin, Higa Nikki, McIntyre David, Ruth Parker S, So Isaac, Kline Enos C, Kanthula Ruth, Wong-On-Wing Annie, Lim Jonathan, Ko Daisy, Milne Ross, Rossouw Theresa, Feucht Ute D, Chung Michael, Jourdain Gonzague, Ngo-Giang-Huong Nicole, Laomanit Laddawan, Soria Jaime, Lai James, Klavins Eric D, Frenkel Lisa M, Lutz Barry R

Abstract excerpt

BACKGROUND: HIV drug resistance (HIVDR) testing can assist clinicians in selecting treatments. However, high complexity and cost of genotyping assays limit routine testing in settings where HIVDR prevalence has reached high levels. METHODS: The oligonucleotide ligation assay (OLA)-Simple kit was developed for detection of HIVDR against first-line non-nucleoside/nucleoside reverse transcriptase inhibitors and...

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Identifiers

PMID: 31767540
DOI: 10.1016/j.ebiom.2019.11.002
PMCID: PMC6921160

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