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Article

Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

2 Dec 2019

Abstract excerpt

Herpes simplex virus (HSV) establishes lifelong latent infection and can cause serious human disease, but current antiviral therapies target lytic but not latent infection. We screened for sgRNAs that cleave HSV-1 DNA sequences efficiently in vitro and used these sgRNAs to observe the first editing of quiescent HSV-1 DNA. The sgRNAs targeted lytic replicating viral DNA genomes more efficiently than quiescent...

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PMID: 31789594
DOI: 10.7554/elife.51662

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