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Article

Reassessing the Association of Sedentary Behavior and Physical Activity with Ischemic Stroke: A Mendelian Randomization Study.

Medicine and science in sports and exercise - 1 Apr 2025

Lin Yidie, Li Xuechao, Hu Meijing, Zhao Jian, Zhu Cairong

Abstract excerpt

PURPOSE: Findings from previous Mendelian randomization (MR) studies disagreed with the current scientific consensus regarding the role of physical activity (PA) and sedentary behavior in ischemic stroke (IS). We reassessed these associations with a focus on etiological subtypes of IS and the potential mediating roles of cardiometabolic traits and brain imaging-derived phenotypes (IDPs). METHODS: We performed MR...

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Topics

Humans
Sedentary Behavior
Mendelian Randomization Analysis
Ischemic Stroke
Exercise
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Brain

Male

Source

Identifiers

PMID: 39809232
DOI: 10.1249/MSS.0000000000003601

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