Article
Identifying novel modifiable risk factors for ischemic stroke through phenome-wide association study and Mendelian randomization analyses in a large-scale prospective cohort.
GeroScience - 1 Jun 2026
Wu Siyu, Li Jialin, Zhao Xinyue, Li Jincheng, Chen Shuaizhou, Zhang Chengtong, Suo Chen, Wang Yingzhe, Chen Xingdong, Cui Mei, Man Qiuhong, Jiang Yanfeng
Abstract excerpt
Despite extensive research, significant uncertainty remains regarding the associations between various risk factors and ischemic stroke (IS). This study aimed to systematically identify and validate a broad range of potential modifiable risk factors for IS. Utilizing genetic and phenotypic data from the UK Biobank (UKB; N = 418,236), we conducted a phenome-wide association study (PheWAS) and Cox regression...
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