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Article

Exploring the causal relationship between sedentary behavior and cardiovascular disease: A two-sample Mendelian randomization analysis.

Medicine - 12 Sept 2025

Cao Ye, Hao Qing, Xia Nan, Feng Yi

Abstract excerpt

Cardiovascular disease (CVD) is the primary cause of death globally. However, the causal association between sedentary behavior (SB) and CVD outcomes remains unknown. Genome-wide association study summary statistics for SB and CVD outcomes were collected from the FinnGen and UK Biobank. Mendelian randomization analyses were applied to explore the causal effects of SB on CVD outcomes by selecting single nucleotide...

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Cardiovascular Diseases
Coronary Artery Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sedentary Behavior

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Identifiers

PMID: 40958285
DOI: 10.1097/MD.0000000000044543
PMCID: PMC12440458

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