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Article

SOX9 regulates ERBB signalling in pancreatic cancer development

21 Oct 2014

Abstract excerpt

OBJECTIVE: The transcription factor SOX9 was recently shown to stimulate ductal gene expression in pancreatic acinar-to-ductal metaplasia and to accelerate development of premalignant lesions preceding pancreatic ductal adenocarcinoma (PDAC). Here, we investigate how SOX9 operates in pancreatic tumourigenesis. DESIGN: We analysed genomic and transcriptomic data from surgically resected PDAC and extended the...

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Identifiers

PMID: 25336113
DOI: 10.1136/gutjnl-2014-307075

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