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Article

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis

9 Apr 2012

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive human malignancies, is thought to be initiated by KRAS activation. Here we find that transcriptional activation mediated by the Gli family of transcription factors, although dispensable for pancreatic development, is required for Kras-induced proliferation and survival in primary pancreatic epithelial cells in culture and for Kras-driven...

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PMID: 22493246
DOI: 10.1073/pnas.1114168109

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