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Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.

Biomolecules - 2 Mar 2021

Chiu Ching-Feng, Hsu Ming-I, Yeh Hsiu-Yen, Park Ji Min, Shen Yu-Shiuan, Tung Te-Hsuan, Huang Jun-Jie, Wu Hung-Tsung, Huang Shih-Yi

Abstract excerpt

BACKGROUND: The oncogenic Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation was reported to be the signature genetic event in most cases of pancreatic ductal adenocarcinoma (PDAC). Hepassocin (HPS/FGL1) is involved in regulating lipid metabolism and the progression of several cancer types; however, the underlying mechanism of HPS/FGL1 in the KRAS mutant PDAC cells undergoing eicosapentaenoic acid (EPA)...

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PMID: 33801246
DOI: 10.3390/biom11030370
PMCID: PMC8001293

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