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Article

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Gastroenterology - 1 May 2015

Chen Nai-Ming, Singh Garima, Koenig Alexander, Liou Geou-Yarh, Storz Peter, Zhang Jin-San, Regul Lisanne, Nagarajan Sankari, Kühnemuth Benjamin, Johnsen Steven A, Hebrok Matthias, Siveke Jens, Billadeau Daniel D, Ellenrieder Volker, Hessmann Elisabeth

Abstract excerpt

BACKGROUND & AIMS: Oncogenic mutations in KRAS contribute to the development of pancreatic ductal adenocarcinoma, but are not sufficient to initiate carcinogenesis. Secondary events, such as inflammation-induced signaling via the epidermal growth factor receptor (EGFR) and expression of the SOX9 gene, are required for tumor formation. Herein we sought to identify the mechanisms that link EGFR signaling...

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Identifiers

PMID: 25623042
DOI: 10.1053/j.gastro.2015.01.033
PMCID: PMC4409493

Genes

EGFR
SOX9
JUN
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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