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Article

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.

Cancer cell - 11 Dec 2012

Kopp Janel L, von Figura Guido, Mayes Erin, Liu Fen-Fen, Dubois Claire L, Morris John P, Pan Fong Cheng, Akiyama Haruhiko, Wright Christopher V E, Jensen Kristin, Hebrok Matthias, Sander Maike

Abstract excerpt

Tumors are largely classified by histologic appearance, yet morphologic features do not necessarily predict cellular origin. To determine the origin of pancreatic ductal adenocarcinoma (PDA), we labeled and traced pancreatic cell populations after induction of a PDA-initiating Kras mutation. Our studies reveal that ductal and stem-like centroacinar cells are surprisingly refractory to oncogenic transformation,...

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Acinar Cells
Carcinoma, Pancreatic Ductal
Genes, ras
Metaplasia
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Precancerous Conditions

SOX9 Transcription Factor

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Identifiers

PMID: 23201164
DOI: 10.1016/j.ccr.2012.10.025
PMCID: PMC3568632

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