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Article

Synthetic rational design of live-attenuated Zika viruses based on a computational model.

Nucleic acids research - 11 Jan 2025

Roopin Modi, Zafrir Zohar, Siridechadilok Bunpote, Suphatrakul Amporn, Julander Justin, Tuller Tamir

Abstract excerpt

Many viruses of the Flaviviridae family, including the Zika virus (ZIKV), are human pathogens of significant public health concerns. Despite extensive research, there are currently no approved vaccines available for ZIKV and specifically no live-attenuated Zika vaccine. In this current study, we suggest a novel computational algorithm for generating live-attenuated vaccines via the introduction of silent mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39797731
DOI: 10.1093/nar/gkae1313
PMCID: PMC11724363

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