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Article

A single-dose live attenuated chimeric vaccine candidate against Zika virus

29 Jan 2021

Abstract excerpt

The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature...

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Insect symbiosis and bacterial influences
Mosquito-borne diseases and control
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33514743
DOI: 10.1038/s41541-021-00282-y

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