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Article

A systematic approach to the development of a safe live attenuated Zika vaccine

6 Mar 2018

Abstract excerpt

Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties similar to the yellow fever 17D (YF17D) live-attenuated vaccine (LAV) would be advantageous, as a single dose of YF17D produces lifelong immunity. However, a replicative ZIKV vaccine must also be safe from causing persistent organ...

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Identifiers

PMID: 29531213
DOI: 10.1038/s41467-018-03337-2

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