Article
Emergence of bedaquiline-resistant tuberculosis and of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains with rpoB Ile491Phe mutation not detected by Xpert MTB/RIF in Mozambique: a retrospective observational study.
The Lancet. Infectious diseases - 1 Mar 2024
Barilar Ivan, Fernando Tatiana, Utpatel Christian, Abujate Cláudio, Madeira Carla Maria, José Benedita, Mutaquiha Claudia, Kranzer Katharina, Niemann Tanja, Ismael Nalia, de Araujo Leonardo, Wirth Thierry, Niemann Stefan, Viegas Sofia
Abstract excerpt
BACKGROUND: In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants of rifampicin-resistant and MDR tuberculosis in Mozambique. METHODS: In this retrospective observational study,...
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