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Article

Dominant negative factors in health and disease.

The Journal of pathology - 1 Aug 2009

Veitia Reiner A

Abstract excerpt

The idea of dominant mutations that interfere with the activity of a normal gene product has been known for more than 80 years-the famous Muller's antimorphs. However, only over half a century later, the mechanistic bases of dominant negative mutations (DNMs) were defined in a systematic way by Ira Herskowitz. Most analyses of DNMs consider only intralocus (interallelic) interactions. The typical textbook...

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PMID: 19544283
DOI: 10.1002/path.2583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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