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Article

Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis.

Drug discovery today - 1 Jul 2014

Kumar Amit, Vaish Manisha, Ratan Rajiv R

Abstract excerpt

Huntington's disease (HD) is a signature polyglutamine disorder. An enduring theory of HD pathogenesis has involved dysregulation of transcription. Indeed, transcriptional regulatory proteins can be modulated to overcome cardinal features of HD-modeled mice, and efforts to move these into human studies are ongoing. Here, we discuss a unifying hypothesis emerging from these studies, which is that HD represents the...

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Identifiers

PMID: 24662036
DOI: 10.1016/j.drudis.2014.03.016
PMCID: PMC4082751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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