Article
CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice.
Scientific reports - 5 Jun 2017
Liu Yongzhen, Qi Xuewei, Zeng Zhenzhen, Wang Lu, Wang Jie, Zhang Ting, Xu Qiang, Shen Congle, Zhou Guangde, Yang Shaomin, Chen Xiangmei, Lu Fengmin
Abstract excerpt
The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of p53 and Pten somatic mutation in HCC development, we established CRISPR/Cas9-mediated somatic gene disruption via hydrodynamic tail vein injection, allowing for in vivo targeting p53 and Pten simultaneously in adult HBV...
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