Article
Induction and preliminary characterization of neoplastic pulmonary nodules in a transgenic pig model.
Lung cancer (Amsterdam, Netherlands) - 1 Apr 2023
Ghosn Mario, Elsakka Ahmed S, Petre Elena N, Cheleuitte-Nieves Christopher, Tammela Tuomas, Monette Sebastien, Ziv Etay, Schachtschneider Kyle M, Srimathveeravalli Govind, Yarmohammadi Hooman, Edward Boas F, Solomon Stephen B
Abstract excerpt
OBJECTIVES: Lung cancer models in large animals are lacking. Oncopigs are transgenic pigs that carry both KRASG12D and TP53R167H Cre-inducible mutations. This study aimed to develop and histologically characterize a swine model of lung cancer that could serve for preclinical studies evaluating locoregional therapies. MATERIALS AND METHODS: In two Oncopigs, an adenoviral vector encoding the Cre-recombinase gene...
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