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Ph+ ALL: new approaches for upfront therapy

6 Dec 2024

Abstract excerpt

Philadelphia chromosome-positive (Ph+) ALL is the most common genetic subtype of ALL and primarily affects adults. Ph+ ALL is characterized by the constitutively active ABL1 kinase and is resistant to conventional chemotherapy. Thus, Ph+ ALL was historically associated with a dismal prognosis, particularly among patients who did not undergo allogeneic hematopoietic stem cell transplantation (alloHCT) in first...

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PMID: 39644078
DOI: 10.1182/hematology.2024000532

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