Modelling hepatocellular carcinoma microenvironment phenotype to evaluate drug efficacy.

Abstract excerpt

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Treating HCC is challenging because of the poor drug effectiveness and the lack of tools to predict patient responses. To resolve these issues, we established a patient-centric spheroid model using HepG2, TWNT-1, and THP-1 co-culture, that mimics HCC phenotype. We developed a target-independent cell killing (TICK)...

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• Anilides
• Coculture Techniques
• Hep G2 Cells
• Phenylurea Compounds
• Pyridines