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In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

1 Jan 2018

Abstract excerpt

Tractable experimental model that accounts for inter-tumor molecular heterogeneity is a key element of anti-cancer drug development. Hepatocellular carcinoma is known to exhibit highly heterogeneous molecular aberrations across the tumors, including somatic genetic and epigenetic alterations. Previous studies showed that molecular tumor subtypes determined by transcriptome, as a comprehensive functional readout,...

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PMID: 29303513
DOI: 10.1038/emm.2017.164

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