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Establishment of a hepatocellular carcinoma patient‐derived xenograft platform and its application in biomarker identification

16 Jul 2019

Abstract excerpt

Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that could be serially passaged, cryopreserved and revived were established. These lines maintained...

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PMID: 31310010
DOI: 10.1002/ijc.32564

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