Article

From 2D Drug Screening to Predictive Pharmacology: Redefining Preclinical Models in Oncology

2026-05-09

Abstract excerpt

Cancer drug development still relies heavily on preclinical models that often fail to predict clinical efficacy. Although two-dimensional (2D) cell cultures and animal models have contributed significantly to cancer research, they do not adequately capture the complexity, heterogeneity, and microenvironmental conditions of human tumors. As a result, pharmacological findings generated with these systems frequently...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09025770-4175-5616-8c19-521477048dc0
DOI: 10.20944/preprints202605.0593.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

From 2D Drug Screening to Predictive Pharmacology: Redefining Preclinical Models in OncologyDOI 10.20944/preprints202605.0593.v1Read

Preclinical Testing Techniques: Paving the Way to New Oncology Screening ApproachesSemantic proximity Read

3D tumor cultures for drug resistance and screening development in clinical applicationsSemantic proximity Read

Breaking the mold: 3D cell cultures reshaping the future of cancer researchSemantic proximity Read

Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery (Review)Semantic proximity Read

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer DrugsSemantic proximity Read

Non-Animal Models for Studying the Effects of Chemotherapeutic Drugs on Breast Cancer MetastasisSemantic proximity Read

Three-dimensional in vitro culture models in oncology researchSemantic proximity Read

Challenges in pre-clinical testing of anti-cancer drugs in cell culture and in animal modelsSemantic proximity Read

Tumor organoids in cancer medicine: from model systems to natural compound screeningSemantic proximity Read

Ex Vivo Tumor Culture Systems for Functional Drug Testing and Therapy Response PredictionSemantic proximity Read

Using 3D in vitro cell culture models in anti-cancer drug discoverySemantic proximity Read

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in CancerSemantic proximity Read