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Article

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression.

Molecular cancer therapeutics - 1 May 2011

van Zijl Franziska, Mall Sabine, Machat Georg, Pirker Christine, Zeillinger Robert, Weinhaeusel Andreas, Bilban Martin, Berger Walter, Mikulits Wolfgang

Abstract excerpt

The epithelial to mesenchymal transition (EMT) of malignant hepatocytes is a crucial event in hepatocellular carcinoma (HCC) progression and recurrence. We aimed to establish a human model of EMT to examine drug efficacy and specificity in HCC progression. Human HCC cell populations were characterized by immunofluorescence analysis, migration and invasion assays, array comparative genomic hybridization,...

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Carcinoma, Hepatocellular
Cell Transformation, Neoplastic
CpG Islands
Drug Screening Assays, Antitumor
Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

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PMID: 21364009
DOI: 10.1158/1535-7163.MCT-10-0917

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