Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs

Abstract excerpt

Background: Hepatocellular carcinoma (HCC) is the leading cause of tumor-related mortality worldwide. There is an urgent need for predictive biomarkers to guide treatment decisions. This study aimed to identify robust prognostic genes for HCC and to establish a theoretical foundation for clinical interventions. Methods: The HCC datasets were obtained from public databases and then differential expression analysis...

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• Cancer Immunotherapy and Biomarkers
• Ferroptosis and cancer prognosis
• Single-cell and spatial transcriptomics