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Whole-Exome Sequencing, Mutational Signature Analysis, and Outcome in Multiple Myeloma-A Pilot Study.

International journal of molecular sciences - 14 Dec 2024

Oelschläger Lorenz, Künstner Axel, Frey Friederike, Leitner Theo, Leypoldt Lisa, Reimer Niklas, Gebauer Niklas, Bastian Lorenz, Weisel Katja, Sailer Verena-Wilbeth, Röcken Christoph, Klapper Wolfram, Konukiewitz Björn, Murga Penas Eva Maria, Forster Michael, Schub Natalie, Ahmed Helal M M, Kirfel Jutta, von Bubnoff Nikolas Christian Cornelius, Busch Hauke, Khandanpour Cyrus

Abstract excerpt

The complex and heterogeneous genomic landscape of multiple myeloma (MM) and many of its clinical and prognostic implications remains to be understood. In other cancers, such as breast cancer, using whole-exome sequencing (WES) and molecular signatures in clinical practice has revolutionized classification, prognostic prediction, and patient management. However, such integration is still in its early stages in...

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PMID: 39769182
DOI: 10.3390/ijms252413418

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