Article
Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases.
PLoS genetics - 1 Nov 2017
Manojlovic Zarko, Christofferson Austin, Liang Winnie S, Aldrich Jessica, Washington Megan, Wong Shukmei, Rohrer Daniel, Jewell Scott, Kittles Rick A, Derome Mary, Auclair Daniel, Craig David Wesley, Keats Jonathan, Carpten John D
Abstract excerpt
Multiple Myeloma (MM) is a plasma cell malignancy with significantly greater incidence and mortality rates among African Americans (AA) compared to Caucasians (CA). The overall goal of this study is to elucidate differences in molecular alterations in MM as a function of self-reported race and genetic ancestry. Our study utilized somatic whole exome, RNA-sequencing, and correlated clinical data from 718 MM...
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