Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations.

Nature cell biology - 1 Feb 2025

Hemalatha Anupama, Li Zongyu, Gonzalez David G, Matte-Martone Catherine, Tai Karen, Lathrop Elizabeth, Gil Daniel, Ganesan Smirthy, Gonzalez Lauren E, Skala Melissa, Perry Rachel J, Greco Valentina

Abstract excerpt

Skin epithelial stem cells correct aberrancies induced by oncogenic mutations. Oncogenes invoke different strategies of epithelial tolerance; while wild-type cells outcompete β-catenin-gain-of-function (βcatGOF) cells, HrasG12V cells outcompete wild-type cells. Here we ask how metabolic states change as wild-type stem cells interface with mutant cells and drive different cell-competition outcomes. By tracking the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Citric Acid Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Gain of Function Mutation

Share to Glucose

Share to Metformin

Share to Oncogenes

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 39762578
DOI: 10.1038/s41556-024-01574-w
PMCID: PMC11821535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations.PMID 39762578Read ↗

Metabolic permissiveness: how tissue context shapes cancer.Semantic proximity Read ↗

Excess dietary sugar impairs colonic epithelial regeneration in response to damageSemantic proximity Read ↗

Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response.Semantic proximity Read ↗

Targeting the glucose-insulin link in head and neck squamous cell carcinoma induces cytotoxic oxidative stress and inhibits cancer growthSemantic proximity Read ↗

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation.Semantic proximity Read ↗

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestineSemantic proximity Read ↗

Mitochondrial oxidation of the carbohydrate fuel driven by pyruvate dehydrogenase robustly enhances stemness of older and geriatric Intestinal Stem CellsSemantic proximity Read ↗

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.Semantic proximity Read ↗

Metabolism regulates muscle stem cell self-renewal by connecting the microenvironment and histone acetylationSemantic proximity Read ↗

The histone methyltransferase G9a regulates tolerance to oxidative stress–induced energy consumptionSemantic proximity Read ↗

Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinomaSemantic proximity Read ↗

Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.