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Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation.

Cell reports - 19 Jun 2018

Hosseini Mohsen, Dousset Léa, Mahfouf Walid, Serrano-Sanchez Martin, Redonnet-Vernhet Isabelle, Mesli Samir, Kasraian Zeinab, Obre Emilie, Bonneu Marc, Claverol Stephane, Vlaski Marija, Ivanovic Zoran, Rachidi Walid, Douki Thierry, Taieb Alain, Bouzier-Sore Anne-Karine, Rossignol Rodrigue, Rezvani Hamid Reza

Abstract excerpt

Although growing evidence indicates that bioenergetic metabolism plays an important role in the progression of tumorigenesis, little information is available on the contribution of reprogramming of energy metabolism in cancer initiation. By applying a quantitative proteomic approach and targeted metabolomics, we find that specific metabolic modifications precede primary skin tumor formation. Using a multistage...

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PMID: 29925003
DOI: 10.1016/j.celrep.2018.05.060

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