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Article

Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames.

RNA biology - 1 Dec 2025

Chen Lei, Gao Xia, Liu Xiangshen, Zhu Ye, Wang Dong

Abstract excerpt

Mutations in PKD1 coding sequence and abnormal PKD1 expression levels contribute to the development of autosomal-dominant polycystic kidney disease, the most common genetic disorder. Regulation of PKD1 expression by factors located in the promoter and 3´ UTR have been extensively studied. Less is known about its regulation by 5´ UTR elements. In this study, we investigated the effects of uORFs and uORF-affecting...

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Share to 5' Untranslated Regions
Share to Conserved Sequence
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to HEK293 Cells

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Source

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Identifiers

PMID: 39757590
DOI: 10.1080/15476286.2024.2448387
PMCID: PMC11810096

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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