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Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome

3 Jan 2025

Abstract excerpt

Chronic hepatitis B virus (HBV) infection can significantly increase the incidence of cirrhosis and liver cancer, and there is no curative treatment. The persistence of HBV covalently closed circular DNA (cccDNA) is the major obstacle of antiviral treatments. cccDNA is formed through repairing viral partially double-stranded relaxed circular DNA (rcDNA) by varies host factors. However, the detailed mechanisms are...

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PMID: 39752632
DOI: 10.1371/journal.ppat.1012824

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